EBM Guidelines for Authors


For details of benefits offered to RSM Press authors, please visit our benefits page.

For details of our policy on depositing articles in institutional or central respositories, please visit our archiving page.

For details of our policy on open access articles, please visit our RSM Open page.

These instructions comply with the Uniform Requirements for Manuscripts Submitted to Biomedical Journals formulated by the International Committee of Medical Journal Editors (for further details, see the ICMJE site)

1. Aims and scope

Experimental Biology and Medicine is particularly appropriate for publication of papers that are multidisciplinary in nature, are of potential interest to a wide audience, and represent experimental medicine in the broadest sense of the term. However, manuscripts reporting novel findings on any topic in the realm of experimental biology and medicine are most welcome. We particularly encourage submission of manuscripts that describe results of studies that require an interdisciplinary approach to biomedical issues. Categories currently listed in EBM are: Anatomy/Pathology; Biochemistry and Molecular Biology; Cell and Developmental Biology; Endocrinology and Nutrition; Immunology/Microbiology/Virology; Neuroscience; Pharmacology and Toxicology; Physiology; Bioimaging; Biomedical Engineering; Bionanoscience; Genomics, Proteomics, and Bioinformatics; Stem Cell Biology; Systems Biology and Translational Research. Authors should indicate their preference of category, although the final decision of reviewing Associate Editor and section Editorial Board rests with the Editor-in-Chief.

2. Editorial policy

Covering letter: The covering letter is important. To help the Editor in his preliminary evaluation, please indicate why you think the paper suitable for publication. If your paper should be considered for fast-track publication, please explain why. The letter must state that the non-signing author(s) have read and approved the manuscript. Any person cited in the manuscript as a source of “personal communication” or “unpublished data” must provide signed approval of such citation.

Peer review: Two reviewers will generally evaluate each manuscript on the basis of scientific rigor of the experimental design, adequacy of the data, validity of the conclusions, importance and originality of the studies, adequacy of the literature citations, clarity of the presentation, and interest to the Journal’s readership. Manuscripts may be returned to the authors without detailed review if, in the opinion of the Editor-in-Chief, they fall outside the scope of interests of the Journal’s readership or if they are not written in clear, concise and grammatical English.

Manuscripts will be given a quality (priority) ranking by each reviewer. Those manuscripts with low priority rankings will not be accepted even though they may have been classed as generally acceptable. If reviewers differ significantly in their opinions, decision will be based on the priority rankings and/or the opinion of an additional reviewer (arbiter). Manuscripts returned after revision based upon reviewers’ comments will be sent back to the original reviewers together with the authors’ responses.

The reviewers’ comments will be held in confidence except as follows: (a) the reviewers’ comments may be sent, in whole or in part, to the corresponding author;(b)after revision, each reviewer’s comments will be sent, in whole or in part, to the other reviewers of the manuscript: and (c) in the event that there is a significant difference in opinion between or among the reviewers, the manuscript may be sent to an additional reviewer (arbiter) together with the comments, in whole or in part, of the other reviewers. In all cases, anonymity of the reviewers will be maintained.

Ethical approval: All research submitted for publication must be approved by an ethics committee.

Use of Human and Animal Subjects and Recombinant DNA- Studies involving human subjects must conform to the ethical standards set by the Belmont Report, Ethical Principles and Guidelines for the Protection of Human Subjects of Research; must have been reviewed and approved by the appropriate institutional Review Board (IRB); and must be presented in such a manner as to assure preservation of the anonymity of the subjects. It must be stated in the Materials and Methods section of the article that the study had been approved by the responsible IRB and that informed consent was obtained from research subjects or it must be explained why IRB review and /or informed consent were not required.

It is the Journal’s policy that all studies involving the use of animals be conducted in compliance with applicable laws and regulations as well as the principles expressed in the National Institutes of Health, USPHS, Guide for the Care and Use of Laboratory Animals, and that the studies be conducted on animals that were lawfully acquired. Use of animals must have been approved by the Institution’s Animal Care and Use Committee (IACUC) and this must be stated in the Materials and Methods section of the article. If the study was conducted in a jurisdiction where such review is not required, this should be noted in the Materials and Methods section. Experiments involving recombinant DNA must have been reviewed and approved as required by applicable laws and regulations.

Patient consent: Any article containing identifiable patient information must be accompanied by a statement of consent to publication. If there is any doubt about whether or not information is identifiable, the Editor-in-Chief is happy to discuss this before an article is submitted. Reviewers will also be asked to take careful account of issues relating to patient confidentiality when reviewing articles.

Each submission should not only be accompanied by a statement of consent, but the Editor-in-Chief also expects to be informed about the measures that have been taken to anonymise the details that could have led to parties being identified. He also reserves the right to work with the authors to make additional anonymising changes as they or the reviewers see fit. The Editor-in-Chief may also ask authors to remove personal information that, whilst interesting and colourful, does not add to the substance of an article, but does increase the likelihood of parties being identified. The exception to this will be where the patient has indicated in writing that she/he wants to be identified, has read the material, has discussed the consequences of being identified, and has agreed to the disclosure of all the personal information contained in the article.

In order to ensure that valuable and novel issues are aired, the Editor-in-Chief will sometimes consider publishing manuscripts that contain potentially identifiable information where it has been impossible or clearly undesirable to seek consent from relevant parties. However, given the strong preference for consent having been sought and obtained the reasons for not seeking consent must be compelling, and the public interest arguments for publishing the case must be powerful. In cases where consent has not been obtained, the authors must provide a statement from a Medical Director or equivalent that the hospital or medical centre is happy for the case to be published.

Financial support, conflict of interest and other declarations: All grant, contract and industrial support of the work included in the manuscript must be acknowledged in a footnote to the title of the manuscript. Commercial relationships of any of the authors that might be viewed as representing a conflict of interest must be disclosed in a footnote to the applicable author’s name. Such disclosure should be made on a separate page as it will not be sent to reviewers or influence editorial decisions but will be included in the published paper.

Permissions: All previously published material must be accompanied by the written consent to reproduction of the copyright holder. An acknowledgement of permission should be included at the relevant point in the paper, and a full reference to the original place of publication should be included in the reference list.

Copyright: Authors of accepted manuscripts will be required to allocate copyright to the Society for Experimental Biology and Medicine (SEBM).

Authors of manuscripts describing original nucleotide or amino acid sequences must submit the sequence to Gen Bank and obtain an accession number from Gen Bank before publication of the manuscript. The accession number should be included in the manuscript as a footnote or in the appropriate figure legend.

When, as a result of reviewers’ comments, it is necessary to revise a manuscript, it is recommended that, unless additional studies are required, the authors should resubmit the revised manuscript promptly; a delay of longer than four months may result in the revised manuscript receiving a lower priority.

If you have any questions regarding submission, please contact the SEBM office:

Society for Experimental Biology and Medicine
197 West Spring Valley Avenue
Maywood, NJ 07607-1727

Tel: 201-291-9080
Fax: 201-291-2988
E-mail: [email protected]

3. Types of articles

Research Articles: Manuscripts are accepted for review with the understanding that the same work has not been and, if accepted by EBM, will not be published elsewhere nor is presently submitted elsewhere; and that its submission for publication has been approved by all of the authors (as confirmed by the covering letter). Unnecessary subdivision of a study into several manuscripts is not acceptable. If any material published previously is included, for clarity or other reasons, this should be indicated with appropriate citation in the manuscript.

One copy of any material that might be regarded as “duplicate publication,” such as preliminary reports (including reviews, symposia and proceedings) or other publications (submitted, in press or published) containing data or other material included in the submitted manuscript, must be sent to the Editor when the manuscript is submitted. Clearly label such material so as to avoid any confusion with the submitted manuscript. Normally it is regarded as acceptable to include in a detailed journal article material that has been presented previously in summary form in reviews, symposia, or conferences, provided appropriate citation is included.

Brief Communications: Manuscripts describing focused studies that are concise and of high impact to a field will be published as Brief Communications. This format is intended for the presentation of scientifically sound and novel research in a clear and concise fashion. The body of the paper should not exceed nine (9) pages of double-spaced text with references. Tables and Figures must also be kept to a minimum (no more than four). Formatting should otherwise follow the requirements for Research Articles.

Minireviews: The journal publishes review articles under the section heading “Minireviews.” Although there is no page limit, the reviews are generally short (~20 pages of double-spaced text with references). They should reflect the state-of-the-art of the area being reviewed and often include a brief history of the field. There is no need to include an exhaustive literature survey. Emphasis upon a particular hypothesis or point of view or upon the personal opinions or interpretation of the writer or upon the work of the writer’s laboratory is appropriate, provided that this focus is clearly indicated in the paper. Most reviews are submitted in response to an invitation from the Editor-in-Chief, and are subjected to the usual review process prior to publication. Unsolicited reviews and reviews solicited by the Associate Editors need to be approved by the Editor-in-Chief before receiving peer review.

Comments: The Journal, at the Editor-in-Chief’s discretion, will publish, under the section heading “Comments,” letters or essays from readers discussing articles that have recently appeared in the Journal or other timely topics of interest to the Journal’s readership. The author of a letter or essay which is published accepts full responsibility for the contents of the letter. Letters discussing a published article may for example include supporting information, clarifications, criticisms, corrections, alternate interpretations or perspectives. Such letters will be sent to the corresponding author of that article prior to publication. If the corresponding or other author wishes, her/his response will be published together with the original letter. At the discretion of the editor, essays or letters discussing controversial issues may be sent to persons representing alternative viewpoints who will be encouraged to provide responses. If the Editor decides to publish such responses, they will be sent to the original author for comments prior to publication. In some cases, the Editor- in-Chief may send a letter or essay for outside review prior to deciding whether to publish it. The Society reserves the right to edit these communications without materially changing their meaning

4. How to submit a manuscript

Only manuscripts submitted via the online manuscript submission and peer review site, which can be found at http://ebm.allentrack.net will be considered for publication.

Please note the following forms must be completed on submission:

EBM Mandatory Submission Form

Conflict of Interest Disclosure form

Assistance with English

All submissions must be in English. If English is not your native language, you may find it helpful to obtain assistance in writing your papers before submitting them to EBM. This may not only save time in the review process but also increase the accuracy of your submission. You can find help in scientific writing at several companies that include:




Please note that neither EBM nor SEBM has used these services and are unable to comment on the quality of their work.

Tables and figures must be submitted as separate individual files, in which case the files should be uploaded in the following order: (1) main text, including title page, abstract and references; (2) tables; (3) figures; and (4) supplementary files.

File formats: Text files must be saved in .doc or .rtf format. Other suitable formats include .tif, .jpg for photographic images, .xls for graphs produced in Excel, and .eps for other line drawings.

5. How to prepare a manuscript

Formatting: Manuscripts should be as concise as possible, yet sufficiently detailed to permit critical appraisal, and should generally not exceed 40 typed pages (including tables, charts and references). They must be submitted using double line-spaced, unjustified text throughout, with headings and subheadings in bold case. Press ‘Enter’ only at the end of a paragraph, list entry or heading.

Title page: The first page should contain the full title of the manuscript, a short title, the author(s) name(s) and affiliation(s), and the name, postal and email addresses of the author for correspondence, as well as a full list of declarations.

The title should be a declarative statement of key findings and should be limited to 15 words. Use of abbreviations in the title should generally be avoided. Research articles should be divided into Abstract, Keywords, Introduction, Materials and Methods, Results, and Discussion sections.

Abstract: An abstract of no more than 300 words must accompany all articles and should not be structured.

Tables: Tables must be prepared using the Table feature of the word processor. Tables should not duplicate information given in the text, should be numbered with Arabic numerals and cited consecutively in the text. Each table should be titled and double-spaced on a separate sheet. Refer to current issues of Experimental Biology and Medicine for the acceptable style of tables. The title of each table should clearly indicate the nature of the contents, and sufficient experimental detail should be included in footnotes to the entries in the table to permit the reader to interpret the results without reference to the text. Units must be clearly indicated for each of the entries in the table.

Figures: All figures should be cited consecutively by Arabic numerals in the text with figure legends typed on a separate sheet. All figures must be accompanied by a figure legend. Legends should contain sufficient experimental detail to permit the figures to be interpreted without reference to the text. Units should be clearly indicated in the figures themselves. All figures and illustrations are to be submitted in such form as to permit photographic reproduction without retouching or redrawing. Line drawings should be no larger than 8.5 x 11.5 inches overall (21 x 27.5 cm). The lettering should be large enough to allow a reduction of two thirds.

Line drawings should be produced electronically and clearly labelled using a sans serif font such as Arial. Graphs may be supplied as Excel spreadsheets (one per sheet). Other line drawings should be supplied in a suitable vector graphic file format (e.g. .eps)

All photographic images should be submitted in camera-ready form (i.e. with all extraneous areas removed), and where necessary, magnification should be shown using a scale marker. Photographic images must be supplied at high resolution, preferably 600 dpi. Images supplied at less than 300 dpi are unsuitable for print and will delay publication. The preferred file format is .tif.

Footnotes: Footnotes in the text should be identified by superscripts consisting of Arabic numerals; footnotes in the tables should be identified by superscript *, †, ‡, §. **, etc., and placed at the bottom of the table.

Statement of Author Contributions and Acknowledgments: This should be typed on a separate page and placed at the end of the text pages.

Authors must include a statement that specifies the actual contribution of each coauthor to the completed work. Formatting of the Statement of Author Contributions is illustrated by the following example:

“All authors participated in the design, interpretation of the studies and analysis of the data and review of the manuscript; MPV, MNS, KAM, and YZ conducted the experiments, RJS supplied critical reagents [or animals] (specify), RAS and WEZ wrote the manuscript, and XYZ contributed [other] (specify).”

Individuals whose contribution does not reach the level required for their inclusion as an author should be acknowledged in the traditional way, with their full names(s) given. For example, “The authors thank Dr. John Doe for advice in statistical analysis”.

The corresponding author must verify that all individuals who made contributions to this study are included either as authors or are acknowledged at the end of the paper.

References: Citations should be used to provide appropriate attribution and credit to previous investigators. Authors are responsible for verifying them against the original source material. Extensive citation should be avoided, if possible, while adhering to the applicable conventions of the scientific community. Authors are responsible for obtaining permission to reproduce from the appropriate sources cited in the text. RSM Press uses the Vancouver referencing system: references should be identified in the text by superscript Arabic numerals after any punctuation, and numbered and listed at the end of the paper in the order in which they are first cited in the text. Automatic numbering should be avoided. References should include the names and initials of all authors. Publications for which no author is apparent may be attributed to the organization from which they originate. Simply omit the name of the author for anonymous journal articles – avoid using ’Anonymous’. Punctuation in references should be kept to a minimum, as shown in the following examples:

1. Baynes J, Dominiczak M. Medical Biochemistry. Philadelphia: Mosby, 1999

2. Abozguia K, Phan TT, Shivu GN, Maher A, Ahmed I, Frenneaux MP. Insights into how to conduct a clinical trial in the UK. J R Soc Med 2007;100:469–72

“Personal communication,” “unpublished,” and “submitted” must be excluded from the reference list and cited in a footnote. If a manuscript being cited has been accepted for publication, include it in the reference list, giving journal, volume, year as available. In general, citation of numerous abstracts is discouraged, although acceptable if necessary to provide proper attribution or credit.

Trade name, popular name or abbreviation when first used must be preceded by the chemical, scientific or technical name; thereafter, any of these names or abbreviations may be used. Trade names should begin with a capital letter. Structural formulas of chemicals should be used only when absolutely necessary.

Abbreviations: Symbols and abbreviations should be those currently in use. Authors should not create new abbreviations and acronyms. The RSM’s book Units, Symbols and Abbreviations provides lists of approved abbreviations.

Units: All measurements should be expressed in SI units.

Statistics: If preparing statistical data for publication, please read the statistical guidelines.

6. Proofs and eprints

Proofs will be sent by email to the designated corresponding author as a PDF file attachment and should be corrected and returned promptly; corrections should be kept to a minimum. Authors will be charged for excessive changes.

Colored illustrations will be published only if the authors cover the costs.

Effective with submissions received after January 1, 2009, all authors are required to pay a part of the cost of publication in the form of a page charge of $70 per page. Authors lacking funding from grant or other sources may apply at the time of submission for a waiver of page charges. Apply for a waiver of page charges on institutional letterhead at the time of submission. The letter can be sent electronically to [email protected], faxed to 201-291-2988 or mailed to SEBM, 197 W. Spring Valley Avenue, Maywood, NJ 07607. Applications must be endorsed by a senior institutional official verifying that no funds are available for paying page charges. A waiver of page charges will not be granted once an initial decision has been rendered on the manuscript. Reprint orders of 1,000 or more should be discussed with the publisher and authors are generally expected to discourage circulation of reprints for commercial purposes.

A PDF eprint of each published article will be supplied free of charge to the author for correspondence; hardcopy offprints may be ordered from the publisher when the proofs are returned.